Inhaled Nitric Oxide in Acute Pulmonary Embolism: A Systematic Review
Tariq Bhat, MD, Adi Neuman, MD, Mohmad Tantary, MD, Hilal Bhat, MD, Daniel Glass, MD, William Mannino, CCRN, Muhammad Akhtar, MD, Alina Bhat, MD, Sumaya Teli, MBChB, James Lafferty, MD
This article reviews the current literature on the use of inhaled nitric oxide in the setting of pulmonary embolism.
The Mystery of High-density Lipoprotein: Quantity or Quality? Review Update on Therapeutic Strategies
Vasiliki Katsi, MD, PhD, Manolis S. Kallistratos, MD, PhD, FESC, Antonios N. Pavlidis, MD, PhD, FACC, Nikos Karpettas, MD, PhD, Ioannis Skoumas, MD, Nikonas Pavleros, MD, Athanasios J. Manolis, MD, FESC, FACC, FAHA, Christos Pitsavos, MD, PhD, FESC, FACE, Dimitris Tousoulis, MD, PhD, FACC, FESC, Christodoulos Stefanadis, MD, PhD, FESC, FACC, Ioannis Kallikazaros, MD, PhD, FESC, FACC
This review summarizes the data challenging the concept that cardiovascular protection through highdensity lipoprotein (HDL) is only associated with its serum concentration. This conventional impression about its protective role now appears obsolete. New aspects of its mechanisms are revealed and novel therapeutic strategies are based on them. However, data from long-term cost-effectiveness studies of treating HDL are still needed. There is a need for biomarkers that represent the functional characteristics of HDL and better quantify the total cardiovascular risk.
Heart Failure With Preserved Ejection Fraction: An Insight Into Its Prevalence, Predictors, and Implications of Early Detection
Muhammad Asrar ul Haq, FRACP, Chiew Wong, PhD, FRACP, David L. Hare, FRACP
A range of conditions has been shown to predispose individuals to development of diastolic dysfunction and heart failure with preserved ejection fraction (HFPEF). Chronic hypertension is the most common cause; it has been suggested that up to 60% of patients with HFPEF are hypertensive. Coronary artery disease, obesity, and diabetes are some of the other common contributory factors. Early detection of asymptomatic patients identified as at risk of developing this syndrome has the potential to reduce the risk of subsequent heart failure; this may be of benefit to focus our attention on prevention and intervention strategies in this population.
Laboratory-induced Mental Stress, Cardiovascular Response, and Psychological Characteristics
Li-Mei Liao, RN, PhD, Mary G. Carey, RN, PhD
This review identifies types of mental stress tests applied in recent research and the exact cardiovascular responses induced by each mental stress test, along with the consideration of the influence of psychological characteristics on cardiovascular reactivity.
Current Advances in Endovascular Therapy for Infrapopliteal Artery Disease
Ibrahim Sidiqi, MD, Patrick Alexander, MD
Peripheral arterial disease (PAD) is a systemic disease with significant morbidity and mortality. A substantial number of patients with PAD have infrapopliteal disease; however, diagnosis based solely on symptoms and ankle-brachial index can lead to delayed or missed opportunities to provide improved quality of life and limb salvage, and potentially reduce mortality. Advances in techniques and devices, and modification of classification systems have shown that an endovascular approach should be the primary therapeutic option for critical limb ischemia resulting from infrapopliteal disease.
Newer Modalities for Imaging Nonischemic Cardiomyopathy
Shuchita Gupta, MD, Aman M. Amanullah MD, PhD, FACC
Cardiomyopathies are practically classified as either ischemic or nonischemic based on the presence or absence of coronary artery disease. Although conventional two-dimensional echocardiography can assess left ventricular ejection fraction, wall motion, and diastolic function, it does not fully capture myocardial mechanics or tissue characterization, and does not accurately identify patients with nonischemic cardiomyopathy (NICMP) at risk for sudden cardiac death. This article discusses advanced imaging modalities for assessment of NICMP, namely, three-dimensional echocardiography, strain imaging, cardiac magnetic resonance, cardiac computed tomography, and sympathetic innervation imaging.
A Novel Inhibitor of Protease-activated Receptor 1: A Review of Chemical Structure and Mode of Action
Mehrnoosh Hashemzadeh, PhD, Joseph M. Arreguin, BS, Tyler Roberts, MS, Mohammad Reza Movahed, MD, PhD
This article reviews this new class of antiplatelet therapy in detail with an acute focus on the TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) and TRA 2°P-TIMI 50 (Trial to Assess the Effects of Vorapaxar in Preventing Heart Attack and Stroke in Patients With Atherosclerosis-Thrombolysis In Myocardial Infarction 50) trials.
Highlights From the Transcatheter Cardiovascular Therapeutics Conference, September 13-17, 2014, Washington DC
Best of the 2014 TCT Annual Meeting
Sandeep K. Krishnan, MD
The author examines important late-breaking clinical research studies and first reports of new data presented at TCT 2014 on the subject of pioneering developments in the realm of interventional cardiology—from valvular heart disease to the duration of dual antiplatelet therapy after percutaneous coronary intervention, to the use of bioresorbable vascular scaffolds to treat coronary artery disease.
The Clot Thickens: Unusual Presentation of a Left Atrial Thrombus
Stephen F. Lau, MD, James S. Hood, MD, Dorinna D. Mendoza, MD, Carolyn Yi Li, MD, Maria Ansari, MD, Jamal S. Rana, MD, PhD
This is an unusual case of a large, free-floating atrial thrombus with a cystic appearance that was surgically removed.
An Example of the Deleterious Effects of Right Ventricular Apical Pacing
Andrés M. Pineda, MD, Omar Issa, DO, Mery Cortes-Bergoderi, MD, Christos G. Mihos, MD, Juan Carlos Brenes, MD, Alfonso Tolentino, MD
Pacemaker implantation remains the mainstay of treatment in patients with symptomatic sinus node disease or severe heart block. Despite the dramatic benefits of this therapy, a high burden of ventricular pacing is known to have its disadvantages. Reported is the case of an 85-year-old woman with a history of sick sinus syndrome who presented with congestive heart failure after her atrioventricular sequential pacemaker defaulted to ventricular pacing mode as a result of battery depletion.
Pulmonary Valve Papillary Fibroelastoma: A Rare Tumor and Rare Location
Hatim Yagoub, MBBS, MSc, Abdullah Sayied Abdullah, MBBS, MRCPI, Abdalla Ibrahim, MBBS, Brendan Meany, MRCPI, Peter Faul, MB, Thomas J. Kiernan, MD
This article reviews a case of an asymptomatic papillary fibroelastoma of the pulmonary valve, incidentally found in a patient who presented with three-vessel coronary artery disease.
Erratum
Now available for your iPhone and iPad
Inhaled Nitric Oxide in Acute Pulmonary Embolism: A Systematic Review
Tariq Bhat, MD, Adi Neuman, MD, Mohmad Tantary, MD, Hilal Bhat, MD, Daniel Glass, MD, William Mannino, CCRN, Muhammad Akhtar, MD, Alina Bhat, MD, Sumaya Teli, MBChB, James Lafferty, MD
This article reviews the current literature on the use of inhaled nitric oxide in the setting of pulmonary embolism.
The Mystery of High-density Lipoprotein: Quantity or Quality? Review Update on Therapeutic Strategies
Vasiliki Katsi, MD, PhD, Manolis S. Kallistratos, MD, PhD, FESC, Antonios N. Pavlidis, MD, PhD, FACC, Nikos Karpettas, MD, PhD, Ioannis Skoumas, MD, Nikonas Pavleros, MD, Athanasios J. Manolis, MD, FESC, FACC, FAHA, Christos Pitsavos, MD, PhD, FESC, FACE, Dimitris Tousoulis, MD, PhD, FACC, FESC, Christodoulos Stefanadis, MD, PhD, FESC, FACC, Ioannis Kallikazaros, MD, PhD, FESC, FACC
This review summarizes the data challenging the concept that cardiovascular protection through highdensity lipoprotein (HDL) is only associated with its serum concentration. This conventional impression about its protective role now appears obsolete. New aspects of its mechanisms are revealed and novel therapeutic strategies are based on them. However, data from long-term cost-effectiveness studies of treating HDL are still needed. There is a need for biomarkers that represent the functional characteristics of HDL and better quantify the total cardiovascular risk.
Heart Failure With Preserved Ejection Fraction: An Insight Into Its Prevalence, Predictors, and Implications of Early Detection
Muhammad Asrar ul Haq, FRACP, Chiew Wong, PhD, FRACP, David L. Hare, FRACP
A range of conditions has been shown to predispose individuals to development of diastolic dysfunction and heart failure with preserved ejection fraction (HFPEF). Chronic hypertension is the most common cause; it has been suggested that up to 60% of patients with HFPEF are hypertensive. Coronary artery disease, obesity, and diabetes are some of the other common contributory factors. Early detection of asymptomatic patients identified as at risk of developing this syndrome has the potential to reduce the risk of subsequent heart failure; this may be of benefit to focus our attention on prevention and intervention strategies in this population.
Laboratory-induced Mental Stress, Cardiovascular Response, and Psychological Characteristics
Li-Mei Liao, RN, PhD, Mary G. Carey, RN, PhD
This review identifies types of mental stress tests applied in recent research and the exact cardiovascular responses induced by each mental stress test, along with the consideration of the influence of psychological characteristics on cardiovascular reactivity.
Current Advances in Endovascular Therapy for Infrapopliteal Artery Disease
Ibrahim Sidiqi, MD, Patrick Alexander, MD
Peripheral arterial disease (PAD) is a systemic disease with significant morbidity and mortality. A substantial number of patients with PAD have infrapopliteal disease; however, diagnosis based solely on symptoms and ankle-brachial index can lead to delayed or missed opportunities to provide improved quality of life and limb salvage, and potentially reduce mortality. Advances in techniques and devices, and modification of classification systems have shown that an endovascular approach should be the primary therapeutic option for critical limb ischemia resulting from infrapopliteal disease.
Newer Modalities for Imaging Nonischemic Cardiomyopathy
Shuchita Gupta, MD, Aman M. Amanullah MD, PhD, FACC
Cardiomyopathies are practically classified as either ischemic or nonischemic based on the presence or absence of coronary artery disease. Although conventional two-dimensional echocardiography can assess left ventricular ejection fraction, wall motion, and diastolic function, it does not fully capture myocardial mechanics or tissue characterization, and does not accurately identify patients with nonischemic cardiomyopathy (NICMP) at risk for sudden cardiac death. This article discusses advanced imaging modalities for assessment of NICMP, namely, three-dimensional echocardiography, strain imaging, cardiac magnetic resonance, cardiac computed tomography, and sympathetic innervation imaging.
A Novel Inhibitor of Protease-activated Receptor 1: A Review of Chemical Structure and Mode of Action
Mehrnoosh Hashemzadeh, PhD, Joseph M. Arreguin, BS, Tyler Roberts, MS, Mohammad Reza Movahed, MD, PhD
This article reviews this new class of antiplatelet therapy in detail with an acute focus on the TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) and TRA 2°P-TIMI 50 (Trial to Assess the Effects of Vorapaxar in Preventing Heart Attack and Stroke in Patients With Atherosclerosis-Thrombolysis In Myocardial Infarction 50) trials.
Highlights From the Transcatheter Cardiovascular Therapeutics Conference, September 13-17, 2014, Washington DC
Best of the 2014 TCT Annual Meeting
Sandeep K. Krishnan, MD
The author examines important late-breaking clinical research studies and first reports of new data presented at TCT 2014 on the subject of pioneering developments in the realm of interventional cardiology—from valvular heart disease to the duration of dual antiplatelet therapy after percutaneous coronary intervention, to the use of bioresorbable vascular scaffolds to treat coronary artery disease.
The Clot Thickens: Unusual Presentation of a Left Atrial Thrombus
Stephen F. Lau, MD, James S. Hood, MD, Dorinna D. Mendoza, MD, Carolyn Yi Li, MD, Maria Ansari, MD, Jamal S. Rana, MD, PhD
This is an unusual case of a large, free-floating atrial thrombus with a cystic appearance that was surgically removed.
An Example of the Deleterious Effects of Right Ventricular Apical Pacing
Andrés M. Pineda, MD, Omar Issa, DO, Mery Cortes-Bergoderi, MD, Christos G. Mihos, MD, Juan Carlos Brenes, MD, Alfonso Tolentino, MD
Pacemaker implantation remains the mainstay of treatment in patients with symptomatic sinus node disease or severe heart block. Despite the dramatic benefits of this therapy, a high burden of ventricular pacing is known to have its disadvantages. Reported is the case of an 85-year-old woman with a history of sick sinus syndrome who presented with congestive heart failure after her atrioventricular sequential pacemaker defaulted to ventricular pacing mode as a result of battery depletion.
Pulmonary Valve Papillary Fibroelastoma: A Rare Tumor and Rare Location
Hatim Yagoub, MBBS, MSc, Abdullah Sayied Abdullah, MBBS, MRCPI, Abdalla Ibrahim, MBBS, Brendan Meany, MRCPI, Peter Faul, MB, Thomas J. Kiernan, MD
This article reviews a case of an asymptomatic papillary fibroelastoma of the pulmonary valve, incidentally found in a patient who presented with three-vessel coronary artery disease.
Erratum
Now available for your iPhone and iPad
Inhaled Nitric Oxide in Acute Pulmonary Embolism: A Systematic Review
Tariq Bhat, MD, Adi Neuman, MD, Mohmad Tantary, MD, Hilal Bhat, MD, Daniel Glass, MD, William Mannino, CCRN, Muhammad Akhtar, MD, Alina Bhat, MD, Sumaya Teli, MBChB, James Lafferty, MD
This article reviews the current literature on the use of inhaled nitric oxide in the setting of pulmonary embolism.
The Mystery of High-density Lipoprotein: Quantity or Quality? Review Update on Therapeutic Strategies
Vasiliki Katsi, MD, PhD, Manolis S. Kallistratos, MD, PhD, FESC, Antonios N. Pavlidis, MD, PhD, FACC, Nikos Karpettas, MD, PhD, Ioannis Skoumas, MD, Nikonas Pavleros, MD, Athanasios J. Manolis, MD, FESC, FACC, FAHA, Christos Pitsavos, MD, PhD, FESC, FACE, Dimitris Tousoulis, MD, PhD, FACC, FESC, Christodoulos Stefanadis, MD, PhD, FESC, FACC, Ioannis Kallikazaros, MD, PhD, FESC, FACC
This review summarizes the data challenging the concept that cardiovascular protection through highdensity lipoprotein (HDL) is only associated with its serum concentration. This conventional impression about its protective role now appears obsolete. New aspects of its mechanisms are revealed and novel therapeutic strategies are based on them. However, data from long-term cost-effectiveness studies of treating HDL are still needed. There is a need for biomarkers that represent the functional characteristics of HDL and better quantify the total cardiovascular risk.
Heart Failure With Preserved Ejection Fraction: An Insight Into Its Prevalence, Predictors, and Implications of Early Detection
Muhammad Asrar ul Haq, FRACP, Chiew Wong, PhD, FRACP, David L. Hare, FRACP
A range of conditions has been shown to predispose individuals to development of diastolic dysfunction and heart failure with preserved ejection fraction (HFPEF). Chronic hypertension is the most common cause; it has been suggested that up to 60% of patients with HFPEF are hypertensive. Coronary artery disease, obesity, and diabetes are some of the other common contributory factors. Early detection of asymptomatic patients identified as at risk of developing this syndrome has the potential to reduce the risk of subsequent heart failure; this may be of benefit to focus our attention on prevention and intervention strategies in this population.
Laboratory-induced Mental Stress, Cardiovascular Response, and Psychological Characteristics
Li-Mei Liao, RN, PhD, Mary G. Carey, RN, PhD
This review identifies types of mental stress tests applied in recent research and the exact cardiovascular responses induced by each mental stress test, along with the consideration of the influence of psychological characteristics on cardiovascular reactivity.
Current Advances in Endovascular Therapy for Infrapopliteal Artery Disease
Ibrahim Sidiqi, MD, Patrick Alexander, MD
Peripheral arterial disease (PAD) is a systemic disease with significant morbidity and mortality. A substantial number of patients with PAD have infrapopliteal disease; however, diagnosis based solely on symptoms and ankle-brachial index can lead to delayed or missed opportunities to provide improved quality of life and limb salvage, and potentially reduce mortality. Advances in techniques and devices, and modification of classification systems have shown that an endovascular approach should be the primary therapeutic option for critical limb ischemia resulting from infrapopliteal disease.
Newer Modalities for Imaging Nonischemic Cardiomyopathy
Shuchita Gupta, MD, Aman M. Amanullah MD, PhD, FACC
Cardiomyopathies are practically classified as either ischemic or nonischemic based on the presence or absence of coronary artery disease. Although conventional two-dimensional echocardiography can assess left ventricular ejection fraction, wall motion, and diastolic function, it does not fully capture myocardial mechanics or tissue characterization, and does not accurately identify patients with nonischemic cardiomyopathy (NICMP) at risk for sudden cardiac death. This article discusses advanced imaging modalities for assessment of NICMP, namely, three-dimensional echocardiography, strain imaging, cardiac magnetic resonance, cardiac computed tomography, and sympathetic innervation imaging.
A Novel Inhibitor of Protease-activated Receptor 1: A Review of Chemical Structure and Mode of Action
Mehrnoosh Hashemzadeh, PhD, Joseph M. Arreguin, BS, Tyler Roberts, MS, Mohammad Reza Movahed, MD, PhD
This article reviews this new class of antiplatelet therapy in detail with an acute focus on the TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) and TRA 2°P-TIMI 50 (Trial to Assess the Effects of Vorapaxar in Preventing Heart Attack and Stroke in Patients With Atherosclerosis-Thrombolysis In Myocardial Infarction 50) trials.
Highlights From the Transcatheter Cardiovascular Therapeutics Conference, September 13-17, 2014, Washington DC
Best of the 2014 TCT Annual Meeting
Sandeep K. Krishnan, MD
The author examines important late-breaking clinical research studies and first reports of new data presented at TCT 2014 on the subject of pioneering developments in the realm of interventional cardiology—from valvular heart disease to the duration of dual antiplatelet therapy after percutaneous coronary intervention, to the use of bioresorbable vascular scaffolds to treat coronary artery disease.
The Clot Thickens: Unusual Presentation of a Left Atrial Thrombus
Stephen F. Lau, MD, James S. Hood, MD, Dorinna D. Mendoza, MD, Carolyn Yi Li, MD, Maria Ansari, MD, Jamal S. Rana, MD, PhD
This is an unusual case of a large, free-floating atrial thrombus with a cystic appearance that was surgically removed.
An Example of the Deleterious Effects of Right Ventricular Apical Pacing
Andrés M. Pineda, MD, Omar Issa, DO, Mery Cortes-Bergoderi, MD, Christos G. Mihos, MD, Juan Carlos Brenes, MD, Alfonso Tolentino, MD
Pacemaker implantation remains the mainstay of treatment in patients with symptomatic sinus node disease or severe heart block. Despite the dramatic benefits of this therapy, a high burden of ventricular pacing is known to have its disadvantages. Reported is the case of an 85-year-old woman with a history of sick sinus syndrome who presented with congestive heart failure after her atrioventricular sequential pacemaker defaulted to ventricular pacing mode as a result of battery depletion.
Pulmonary Valve Papillary Fibroelastoma: A Rare Tumor and Rare Location
Hatim Yagoub, MBBS, MSc, Abdullah Sayied Abdullah, MBBS, MRCPI, Abdalla Ibrahim, MBBS, Brendan Meany, MRCPI, Peter Faul, MB, Thomas J. Kiernan, MD
This article reviews a case of an asymptomatic papillary fibroelastoma of the pulmonary valve, incidentally found in a patient who presented with three-vessel coronary artery disease.
Erratum
Now available for your iPhone and iPad