Sipuleucel-T for the Treatment of Patients With Metastatic Castrate-resistant Prostate Cancer: Considerations for Clinical Practice
Christopher M. Pieczonka, MD, Dimitrios Telonis, BA, Vladimir Mouraviev, MD, David Albala, MD
Sipuleucel-T treatment is associated with a significant and consistent survival benefit in patients with metastatic castrate-resistant prostate cancer and is now being used in the clinic for patients with a lower disease burden. The authors present their experience with the use of sipuleucel-T in the setting of a large urology practice.
Fertility Preservation Options for Men and Women With Cancer
Malgorzata E. Skaznik-Wikiel, MD, Sara Babcock Gilbert, MD, Randall B. Meacham, MD, Laxmi A. Kondapalli, MD, MSCE
Approximately 0.2% of Americans aged 20 to 39 years are childhood cancer survivors. Advances in cancer detection and therapy have greatly improved survival rates for young cancer patients; however, treatment of childhood cancers can adversely impact reproductive function. Many cancer patients report a strong desire to be informed of existing options for fertility preservation and future reproduction prior to initiation of gonadotoxic cancer therapies, including surgery, chemotherapy, and radiotherapy. This article discusses, in detail, the effects of cancer treatment on fertility in men and women, and outlines both current and experimental methods of fertility preservation among cancer patients.
Smoking: Its Impact on Urologic Health
David Mobley, MD, Neil Baum, MD
This article points out the various urologic conditions associated with smoking and tobacco use with the intention of providing physicians and patients with knowledge and education regarding this connection.
Can Serum Testosterone Be Used as a Marker of Overall Health?
Michael A. Mederos, Aaron M. Bernie, MD, Jason M. Scovell, Ranjith Ramasamy, MD
Low serum testosterone has been associated with obesity, type 2 diabetes, metabolic syndrome, and atherosclerosis. Individuals with these comorbidities are at increased risk of premature death and other adverse health effects. Clinical data portend low testosterone as a risk factor for developing these conditions, which are supported by the hypogonadal-obesity-adipocytokine hypothesis. The authors support comprehensive evaluation for these comorbid conditions in men found to have low serum testosterone.
The 4Kscore® Test Reduces Prostate Biopsy Rates in Community and Academic Urology Practices
Badrinath Konety, MD, Stephen M. Zappala, MD, Dipen J. Parekh, MD, Danielle Osterhout, Jeffrey Schock, DO, Randy M. Chudler, MD, Gregory M. Oldford, MD, Kenneth M. Kernen, MD, Jason Hafron, MD
The 4Kscore Test, as a follow-up test for an abnormal prostate-specific antigen and/or digital rectal examination results, significantly influenced the physician and patient shared decision in clinical practice, which led to a reduction in prostate biopsies while increasing the probability of detecting aggressive cancer.
Effectiveness of Antegrade Access in Bladder Tumors With Inaccessible Urethra
Abdul Rouf Khawaja, MS DNB (Urology),Tanveer Iqbal Dar, MS DNB (Urology), Sajad Maik, MS DNB (Urology), Javaid Magray, MS (Surgery), Ashiq Bhat, MS, Mch trainee (Urology), Arif Hameed Bhat, Mch (Urology), Mohd. Saleem Wani, Mch (Urology), Baldev Singh Wazir, MS, FICS (Urology)
The authors present 12 cases of bladder tumor with inaccessible urethra, 10 cases due to multiple strictures (post-transurethral resection of bladder tumor [TURBT] and/or transurethral resection of the prostate), and 2 cases due to urethrocutaneous fistulas (post-TURBT), who presented with acute urinary retention. Emergent suprapubic catheterization was used as a temporary treatment method.
Acromegaly Presenting as Erectile Dysfunction: Case Reports and Review of the Literature
Jerry A. Raju, BMBCh, MA (Oxon), MRCS, Kate E. Shipman, BMBCh, MA (Oxon), MRCP, FRCPath, John A. Inglis, MBChB, MD, FRCS,1Rousseau Gama, MBChB, MD, FRCP, FRCPath
The authors report two cases of acromegaly presenting with erectile dysfunction (ED) and hypogonadotropic hypogonadism. Surgical cure of the acromegaly was associated with either an improvement or resolution of hypogonadotropic hypogonadism-associated ED. Active acromegaly should be considered in the differential diagnosis of ED presenting with supporting clinical features, particularly hypogonadotropic hypogonadism.
Sorafenib-induced Scrotal Eczema
Selahattin Çalişkan, MD
A case of a patient treated with sorafenib for metastatic renal cell carcinoma who developed scrotal eczema is reported.
Sipuleucel-T for the Treatment of Patients With Metastatic Castrate-resistant Prostate Cancer: Considerations for Clinical Practice
Christopher M. Pieczonka, MD, Dimitrios Telonis, BA, Vladimir Mouraviev, MD, David Albala, MD
Sipuleucel-T treatment is associated with a significant and consistent survival benefit in patients with metastatic castrate-resistant prostate cancer and is now being used in the clinic for patients with a lower disease burden. The authors present their experience with the use of sipuleucel-T in the setting of a large urology practice.
Fertility Preservation Options for Men and Women With Cancer
Malgorzata E. Skaznik-Wikiel, MD, Sara Babcock Gilbert, MD, Randall B. Meacham, MD, Laxmi A. Kondapalli, MD, MSCE
Approximately 0.2% of Americans aged 20 to 39 years are childhood cancer survivors. Advances in cancer detection and therapy have greatly improved survival rates for young cancer patients; however, treatment of childhood cancers can adversely impact reproductive function. Many cancer patients report a strong desire to be informed of existing options for fertility preservation and future reproduction prior to initiation of gonadotoxic cancer therapies, including surgery, chemotherapy, and radiotherapy. This article discusses, in detail, the effects of cancer treatment on fertility in men and women, and outlines both current and experimental methods of fertility preservation among cancer patients.
Smoking: Its Impact on Urologic Health
David Mobley, MD, Neil Baum, MD
This article points out the various urologic conditions associated with smoking and tobacco use with the intention of providing physicians and patients with knowledge and education regarding this connection.
Can Serum Testosterone Be Used as a Marker of Overall Health?
Michael A. Mederos, Aaron M. Bernie, MD, Jason M. Scovell, Ranjith Ramasamy, MD
Low serum testosterone has been associated with obesity, type 2 diabetes, metabolic syndrome, and atherosclerosis. Individuals with these comorbidities are at increased risk of premature death and other adverse health effects. Clinical data portend low testosterone as a risk factor for developing these conditions, which are supported by the hypogonadal-obesity-adipocytokine hypothesis. The authors support comprehensive evaluation for these comorbid conditions in men found to have low serum testosterone.
The 4Kscore® Test Reduces Prostate Biopsy Rates in Community and Academic Urology Practices
Badrinath Konety, MD, Stephen M. Zappala, MD, Dipen J. Parekh, MD, Danielle Osterhout, Jeffrey Schock, DO, Randy M. Chudler, MD, Gregory M. Oldford, MD, Kenneth M. Kernen, MD, Jason Hafron, MD
The 4Kscore Test, as a follow-up test for an abnormal prostate-specific antigen and/or digital rectal examination results, significantly influenced the physician and patient shared decision in clinical practice, which led to a reduction in prostate biopsies while increasing the probability of detecting aggressive cancer.
Effectiveness of Antegrade Access in Bladder Tumors With Inaccessible Urethra
Abdul Rouf Khawaja, MS DNB (Urology),Tanveer Iqbal Dar, MS DNB (Urology), Sajad Maik, MS DNB (Urology), Javaid Magray, MS (Surgery), Ashiq Bhat, MS, Mch trainee (Urology), Arif Hameed Bhat, Mch (Urology), Mohd. Saleem Wani, Mch (Urology), Baldev Singh Wazir, MS, FICS (Urology)
The authors present 12 cases of bladder tumor with inaccessible urethra, 10 cases due to multiple strictures (post-transurethral resection of bladder tumor [TURBT] and/or transurethral resection of the prostate), and 2 cases due to urethrocutaneous fistulas (post-TURBT), who presented with acute urinary retention. Emergent suprapubic catheterization was used as a temporary treatment method.
Acromegaly Presenting as Erectile Dysfunction: Case Reports and Review of the Literature
Jerry A. Raju, BMBCh, MA (Oxon), MRCS, Kate E. Shipman, BMBCh, MA (Oxon), MRCP, FRCPath, John A. Inglis, MBChB, MD, FRCS,1Rousseau Gama, MBChB, MD, FRCP, FRCPath
The authors report two cases of acromegaly presenting with erectile dysfunction (ED) and hypogonadotropic hypogonadism. Surgical cure of the acromegaly was associated with either an improvement or resolution of hypogonadotropic hypogonadism-associated ED. Active acromegaly should be considered in the differential diagnosis of ED presenting with supporting clinical features, particularly hypogonadotropic hypogonadism.
Sorafenib-induced Scrotal Eczema
Selahattin Çalişkan, MD
A case of a patient treated with sorafenib for metastatic renal cell carcinoma who developed scrotal eczema is reported.
Sipuleucel-T for the Treatment of Patients With Metastatic Castrate-resistant Prostate Cancer: Considerations for Clinical Practice
Christopher M. Pieczonka, MD, Dimitrios Telonis, BA, Vladimir Mouraviev, MD, David Albala, MD
Sipuleucel-T treatment is associated with a significant and consistent survival benefit in patients with metastatic castrate-resistant prostate cancer and is now being used in the clinic for patients with a lower disease burden. The authors present their experience with the use of sipuleucel-T in the setting of a large urology practice.
Fertility Preservation Options for Men and Women With Cancer
Malgorzata E. Skaznik-Wikiel, MD, Sara Babcock Gilbert, MD, Randall B. Meacham, MD, Laxmi A. Kondapalli, MD, MSCE
Approximately 0.2% of Americans aged 20 to 39 years are childhood cancer survivors. Advances in cancer detection and therapy have greatly improved survival rates for young cancer patients; however, treatment of childhood cancers can adversely impact reproductive function. Many cancer patients report a strong desire to be informed of existing options for fertility preservation and future reproduction prior to initiation of gonadotoxic cancer therapies, including surgery, chemotherapy, and radiotherapy. This article discusses, in detail, the effects of cancer treatment on fertility in men and women, and outlines both current and experimental methods of fertility preservation among cancer patients.
Smoking: Its Impact on Urologic Health
David Mobley, MD, Neil Baum, MD
This article points out the various urologic conditions associated with smoking and tobacco use with the intention of providing physicians and patients with knowledge and education regarding this connection.
Can Serum Testosterone Be Used as a Marker of Overall Health?
Michael A. Mederos, Aaron M. Bernie, MD, Jason M. Scovell, Ranjith Ramasamy, MD
Low serum testosterone has been associated with obesity, type 2 diabetes, metabolic syndrome, and atherosclerosis. Individuals with these comorbidities are at increased risk of premature death and other adverse health effects. Clinical data portend low testosterone as a risk factor for developing these conditions, which are supported by the hypogonadal-obesity-adipocytokine hypothesis. The authors support comprehensive evaluation for these comorbid conditions in men found to have low serum testosterone.
The 4Kscore® Test Reduces Prostate Biopsy Rates in Community and Academic Urology Practices
Badrinath Konety, MD, Stephen M. Zappala, MD, Dipen J. Parekh, MD, Danielle Osterhout, Jeffrey Schock, DO, Randy M. Chudler, MD, Gregory M. Oldford, MD, Kenneth M. Kernen, MD, Jason Hafron, MD
The 4Kscore Test, as a follow-up test for an abnormal prostate-specific antigen and/or digital rectal examination results, significantly influenced the physician and patient shared decision in clinical practice, which led to a reduction in prostate biopsies while increasing the probability of detecting aggressive cancer.
Effectiveness of Antegrade Access in Bladder Tumors With Inaccessible Urethra
Abdul Rouf Khawaja, MS DNB (Urology),Tanveer Iqbal Dar, MS DNB (Urology), Sajad Maik, MS DNB (Urology), Javaid Magray, MS (Surgery), Ashiq Bhat, MS, Mch trainee (Urology), Arif Hameed Bhat, Mch (Urology), Mohd. Saleem Wani, Mch (Urology), Baldev Singh Wazir, MS, FICS (Urology)
The authors present 12 cases of bladder tumor with inaccessible urethra, 10 cases due to multiple strictures (post-transurethral resection of bladder tumor [TURBT] and/or transurethral resection of the prostate), and 2 cases due to urethrocutaneous fistulas (post-TURBT), who presented with acute urinary retention. Emergent suprapubic catheterization was used as a temporary treatment method.
Acromegaly Presenting as Erectile Dysfunction: Case Reports and Review of the Literature
Jerry A. Raju, BMBCh, MA (Oxon), MRCS, Kate E. Shipman, BMBCh, MA (Oxon), MRCP, FRCPath, John A. Inglis, MBChB, MD, FRCS,1Rousseau Gama, MBChB, MD, FRCP, FRCPath
The authors report two cases of acromegaly presenting with erectile dysfunction (ED) and hypogonadotropic hypogonadism. Surgical cure of the acromegaly was associated with either an improvement or resolution of hypogonadotropic hypogonadism-associated ED. Active acromegaly should be considered in the differential diagnosis of ED presenting with supporting clinical features, particularly hypogonadotropic hypogonadism.
Sorafenib-induced Scrotal Eczema
Selahattin Çalişkan, MD
A case of a patient treated with sorafenib for metastatic renal cell carcinoma who developed scrotal eczema is reported.